Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis

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Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis.

Angiogenesis is important for normal growth and wound healing processes. An imbalance of the growth factors involved in this process, however, causes the acceleration of several diseases including malignant, ocular, and inflammatory diseases. Inhibiting angiogenesis through interfering with its pathway is a promising methodology to hinder the progression of these diseases. Herein, we studied th...

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The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investigated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhibited the proliferation of human umbilical vein endothelial cells (HUVEC) that was induced by the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFG...

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Vascular Endothelial Growth Factor and Angiogenesis

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 2007

ISSN: 0014-5793

DOI: 10.1016/j.febslet.2007.02.022